Biology Part I (Grade XI)
Bachelor of Medicine, Bachelor of Surgery (MBBS) syllabus recommended by Aga Khan University (AKU).
Biology Part I
| Topics and Sub-topics | Student Learning Outcomes | Cognitive Level | ||
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1. Introduction to Biology |
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| 1.1 Major Fields of Specialisation in Biology | 1.1.1 Differentiate among the branches of biology (fresh water biology, marine biology, sociobiology, veterinary science and bioclimatology); | * | ||
| 1.2 Levels of Biological Organisation | 1.2.1 Differentiate among the levels of biological organisation from subatomic particles to biosphere; | * | ||
| 1.3 Biological Method | 1.3.1 Exemplify deductive and inductive reasoning; 1.3.2 Differentiate among hypothesis, theory and scientific law; |
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| 1.4 Services of Biology | 1.4.1 Discuss the role of biology with respect to disease control in plants and animals:
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2. Biological Molecules |
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| 2.1 Introduction to Biochemistry | – Define biochemistry and biological molecules – State the chemical composition of protoplasm – Differentiate between organic and inorganic molecules – Differentiate among covalent, ionic bond and hydrogen bond |
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| 2.2 Properties of Carbon | 2.2.1 Describe properties of carbon (tetra-valency, isomerism and catenation); 2.2.2 Describe polarity of water molecules that results in hydrogen bonding; 2.2.3 Discuss properties of water that contribute to the sustainability of life on Earth:
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| 2.3 Chemical Nature and Importance of Water | 2.3.1 Describe polarity of water molecules that results in hydrogen bonding; 2.3.2 Discuss properties of water that contribute to the sustainability of life on Earth:
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| 2.4 Carbohydrates | 2.4.1 Define carbohydrates; 2.4.2 Describe properties of monosaccharides, disaccharides and polysaccharides with examples; 2.4.3 Differentiate between condensation and hydrolysis; 2.4.4 Illustrate the formation and breakage of disaccharides (maltose, sucrose and lactose); 2.4.5 Compare structure and function of starch, cellulose, glycogen and chitin; |
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| 2.5 Lipids | 2.5.1 Define lipids; 2.5.2 Describe the properties of acylglycerols, phospholipids, terpenoids and waxes; 2.5.3 Illustrate the molecular structure of an acylglycerol (triglyceride), a phospholipid and a terpene; 2.5.4 Describe the roles of steroids and prostaglandins in living organisms; |
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| 2.6 Proteins | 2.6.1 Define proteins and amino acids; 2.6.2 Illustrate the structure of amino acids; 2.6.3 Illustrate synthesis and breakage of peptide linkage; 2.6.4 Differentiate between: a. Essential and non-essential amino acids b. Acidic and basic amino acids c. Polar and non-polar amino acids; 2.6.5 Explain amphoteric property of amino acids; 2.6.6 Differentiate between dipeptides and polypeptides; 2.6.7 Differentiate among levels of organisation of proteins: a. Primary b. Secondary c. Tertiary d. Quaternary; 2.6.8 Define fibrous and globular proteins; 2.6.9 Exemplify significance of sequence of amino acids in a polypeptide chain through sickle cell anaemia; 2.6.10 List functions of proteins in the body; |
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| 2.7 Nucleic Acids | 2.7.1 Define nucleic acid; 2.7.2 Differentiate between nucleotide and nucleoside; 2.7.3 Illustrate structure of deoxyribonucleic acid (DNA); 2.7.4 Classify nucleotides on the basis of their sugar molecules and nitrogen bases; 2.7.5 Differentiate between a mononucleotide (ATP) and a dinucleotide (NAD); 2.7.6 Define genetic code; 2.7.7 Differentiate among different types of RNA molecules with reference to their role in protein synthesis; |
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| 2.8 Conjugated Molecules | 2.8.1 Define conjugated molecules; 2.8.2 Describe functions of glycolipids, glycoproteins, lipoproteins and nucleoproteins. |
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3. Enzymes |
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| 3.1 Structure of Enzyme | 3.1.1 Describe enzyme, cofactor (prosthetic group and coenzyme with examples), apoenzyme and holoenzyme; | * | ||
| 3.2 Characteristics of Enzymes | 3.2.1 Describe characteristics of enzymes; | * | ||
| 3.3 Mechanism of Enzyme Action | 3.3.1 Compare lock and key model and induced fit model of enzyme action; 3.3.2 Illustrate the mechanism of enzyme action through lock and key model and induced fit model; 3.3.3 Define energy of activation; 3.3.4 Explain that enzymes speed up a chemical reaction by lowering the energy of activation using graphs; |
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| 3.4 Factors Affecting Enzyme Action | 3.4.1 Verify the effect of different factors (pH and temperature) on the rate of enzyme action using graph; 3.4.2 Compare optimum temperature of human body enzymes and thermophilic bacteria; 3.4.3 Compare optimum pH of different enzymes like trypsin and pepsin; |
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| 3.5 Enzyme Inhibition | 3.5.1 Classify inhibitors into competitive and non-competitive inhibitors; 3.5.2 Describe the significance of inhibitors; 3.5.3 Explain feedback inhibition; |
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| 3.6 Classification of Enzymes | 3.6.1 Classify enzymes on the basis of reactions they catalyse and nature of substrate. | * | ||
4. The Cell |
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| 4.1 Discovery of Cell | 4.1.1 State the contributions of different scientists in the discovery of cell (Robert Hooke 1665 to August Weismann 1880); | |||
| 4.2 Microscope | 4.2.1 Apply the concept of resolution versus magnification of a microscope; | * | ||
| 4.3 Techniques used in Cell Biology | 4.3.1 Describe the techniques used in cell biology:
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| 4.4 Structure of Animal and Plant Cell | 4.4.1 Explain structure, chemical composition and functions of the cellular organelles of animal and plant cell as revealed through the electron microscope:
4.4.2 Describe storage diseases with reference to the malfunctioning of lysosomes;
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5. Classification and Acellular Life |
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| 5.1 Classification of Living Organisms | 5.1.1 Describe basis of classification of living organisms (homology, biochemistry, cytology and genetics); 5.1.2 Exemplify hierarchy of biological classification (species, genera, family, order, class, phylum/division and kingdom); |
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| 5.2 Nomenclature | 5.2.1 Describe binomial nomenclature; 5.2.2 Describe the significance of binomial nomenclature; |
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| 5.3 Two and Five-Kingdom System | 5.3.1 Compare kingdoms of living organisms:
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| 5.4 Characteristics of Viruses | 5.4.1 Trace the discovery of viruses; 5.4.2 State characteristic features of viruses; 5.4.3 Explain how viruses survive inside a host cell; |
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| 5.5 Classification of Viruses | 5.5.1 Classify viruses on the basis of their structure, type of nucleic acid and host; 5.5.2 List diseases caused by viruses in animals and plants; |
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| 5.6 Life Cycle of Viruses | 5.6.1 Compare lytic and lysogenic life cycle of a bacteriophage; 5.6.2 Discuss use of a bacteriophage in genetic engineering; |
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| 5.7 Viral Diseases | 5.7.1 Describe causative agent, symptoms, treatment and preventive measures of viral diseases:
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| 5.8 Prions and Viroids | 5.8.1 Differentiate between prions and viroids; 5.8.2 List diseases caused by prions and viroids; |
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| 5.9 Economic and Human Loss by Viruses | 5.9.1 Discuss the loss of economic and human resources caused by viral epidemics using Zika and Ebola as examples; | * | ||
6. Kingdom Prokaryotae |
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| 6.1 Characteristic Features of Prokaryotes | 6.1.1 State characteristic features of prokaryotes; | * | ||
| 6.2 Morphology of Bacteria | 6.2.1 State characteristic features of archaebacteria (thermophilic, acidophilic and halophilic); 6.2.2 Describe discovery, occurrence and habitat of bacteria; 6.2.3 Describe morphological diversity (shapes) of bacteria; 6.2.4 Differentiate between gram positive and gram negative bacteria with reference to their color and composition of cell wall; 6.2.5 Relate the function of each component of bacterial cell with its structure:
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| 6.3 Nutrition in Bacteria | 6.3.1 Differentiate between the types of nutrition in bacteria:
6.3.2 Differentiate between the chlorophyll present in bacteria and plants; |
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| 6.4 Respiration in Bacteria | 6.4.1 Describe obligatory aerobes, micro-aerobes, facultative and obligatory anaerobes; | * | ||
| 6.5 Locomotion in Bacteria | 6.5.1 Compare methods of locomotion in bacteria (chemotaxis and magnetotaxis); | * | ||
| 6.6 Growth in Bacteria | 6.6.1 Explain different phases of growth in bacteria using graph; | * | ||
| 6.7 Reproduction in Bacteria | 6.7.1 Differentiate among different modes of reproduction in bacteria:
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| 6.8 Economic Importance of Bacteria | 6.8.1 Discuss role of beneficial bacteria in:
6.8.2 Discuss role of harmful bacteria in:
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| 6.9 Control and Prevention of Bacteria | 6.9.1 Describe different physical and chemical methods to control bacteria; 6.9.2 Describe immunisation (vaccination); 6.9.3 List uses and misuses of antibiotics; |
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| 6.10 Cyanobacteria | 6.10.1 List general characteristics of cyanobacteria; 6.10.2 Describe habitat, structure, nutrition and reproduction in nostoc; 6.10.3 Describe role of cyanobacteria in nitrogen fixation; |
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7. Kingdom Protista (Protocrista) |
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| 7.1 Unifying Features | 7.1.1 Describe characteristics of protists; | * | ||
| 7.2 Diversity among Protists | 7.2.1 Trace evolutionary relationship among protists; | * | ||
| 7.3 Animal-like Protists | 7.3.1 Describe salient features of animal-like protists; 7.3.2 Classify animal-like protists on the basis of their locomotory organelles with examples; 7.3.3 List the pathogenic protozoan and diseases caused by them; |
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| 7.4 Plant-like Protists | 7.4.1 Describe salient features of plant-like protists; 7.4.2 Classify photosynthetic protists; 7.4.3 Differentiate among brown, red and green algae; |
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| 7.5 Fungus-like Protists | 7.5.1 Compare features of myxomycota and oomycota; 7.5.2 State importance of Phytophthora infestans; |
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8. Kingdom Fungi |
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| 8.1 General Characteristics | 8.1.1 Differentiate between fungi and organisms of other kingdoms on the basis of their characteristic features; 8.1.2 Describe structure and nutrition in fungi; 8.1.3 Compare lichens with mycorrhizae; 8.1.4 Explain different methods of asexual and sexual reproduction in fungi; |
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| 8.2 Classification of Fungi | 8.2.1 Differentiate among main groups of fungi based on their reproductive structures and methods of reproduction; | * | ||
| 8.3 Land Adaptations of Fungi | 8.3.1 Describe adaptive features of fungi in the land habitat; | * | ||
| 8.4 Importance of Fungi | 8.4.1 Discuss ecological and commercial importance of fungi; 8.4.2 Discuss economic losses due to fungi; |
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9. Kingdom Plantae |
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| 9.1 Diversity among Plants | 9.1.1 State general characteristics of plants; 9.1.2 Describe phylogeny of kingdom plantae; 9.1.3 Classify kingdom plantae; |
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| 9.2 Bryophytes | 9.2.1 State characteristic features of bryophytes; 9.2.2 Classify bryophytes as musci, hepatice or anthocerotae; 9.2.3 Explain the life cycle of mosses; 9.2.4 Describe the significance of alternation of generation in bryophytes; 9.2.5 Discuss the adaptive characteristics of bryophytes in the land habitat; |
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| 9.3 Tracheophyta | 9.3.1 Compare major groups of tracheophyta:
9.3.2 Explain evolution of single-veined (microphyllus) and multi-veined (megaphyllus) leaf; |
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| 9.4 Seed Plants | 9.4.1 Describe general characteristics of gymnosperms and angiosperms; 9.4.2 Explain life cycle of pinus (gymnosperm) with diagram; 9.4.3 Explain life cycle of an angiosperm with diagram; 9.4.4 Compare dicotyledonous and monocotyledonous plant; |
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| 9.5 Angiospermic Families | 9.4.5 Discuss that vascular plants are the most successful group of land plants; 9.5.1 Differentiate among vegetative characteristics, floral characteristics and economic importance of angiospermic families:
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10. Kingdom Animalia |
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| 10.1 Introduction | 10.1.1 Describe general characteristics of animals; | * | ||
| 10.2 Criteria for Animal Classification | 10.2.1 Differentiate among various phyla of kingdom animalia on the basis of their body plan:
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| 10.3 Phylum Porifera | 10.3.1 Explain general characteristics of poriferans; 10.3.2 Describe the economic importance of poriferans; |
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| 10.4 Grade Radiata Phylum Coelenterata | 10.4.1 Explain coelenterates with reference to their:
10.4.2 Describe the economic importance of coelenterates; |
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| 10.5 Grade Bilateria Triploblastic Animals-Acoelomates Phylum Platyhelminthes | 10.5.1 Explain general characteristics of platyhelminthes; 10.5.2 Describe the adaptations for parasitic mode of life in platyhelminthes; |
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| 10.6 Grade Bilateria Triploblastic Animals-Pseudocoelomates Phylum Aschelminthes (Nematoda) | 10.6.1 Explain nematodes with reference to their:
10.6.2 Describe the importance of nematodes; |
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| 10.7 Grade Bilateria Triploblastic Animals-Coelomates Phylum Annelida | 10.7.1 Explain annelids with reference to their:
10.7.2 Classify annelids up to classes; |
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| 10.8 Phylum Arthropoda | 10.8.1 Explain general characteristics of arthropods; 10.8.2 Describe the major classes of arthropods:
10.8.3 Describe metamorphosis in insects; |
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| 10.9 Phylum Mollusca | 10.9.1 Explain general characteristics of molluscs; 10.9.2 Describe characteristics of classes of molluscs:
10.9.3 Describe the economic importance of molluscs; |
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| 10.10 Phylum Echinodermata | 10.10.1 Explain general characteristics of spiny skinned animals (echinoderms) and their affinities; | * | ||
| 10.11 Phylum Hemichordata | 10.11.1 Describe the basic characteristics of hemichordates; | * | ||
| 10.12 Phylum Chordata | 10.12.1 Describe fundamental characteristics of chordates; 10.12.2 Classify chordates; 10.12.3 Differentiate between:
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| 10.13 Sub-phylum Vertebrata | 10.13.1 Describe general characteristics of super-class pisces; 10.13.2 Differentiate among cyclostomes, chondrichthyes (cartilaginous) and osteichthyes (bony fishes); 10.13.3 Describe aquatic adaptations of super-class pisces; 10.13.4 List some familiar edible fishes in Pakistan; 10.13.5 Explain origin and general characteristics of amphibians; 10.13.6 Discuss amphibians as unsuccessful land vertebrates; 10.13.7 Explain general characteristics of reptiles; 10.13.8 Discuss reptiles as successful land vertebrates; 10.13.9 Describe general characteristics of birds; 10.13.10 Explain the adaptations of birds for aerial mode of life (flight adaptations); 10.13.11 Exemplify running and flying birds; 10.13.12 Trace the evolutionary origin of birds with reference to archaeopteryx; 10.13.13 Trace the evolutionary origin of mammals; 10.13.14 Describe general characteristics and classification of mammals (prototheria, metatheria and eutheria); |
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11. Bioenergetics |
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| 11.1 Role of ATP | 11.1.1 Define bioenergetics; 11.1.2 Describe the role of ATP as currency of energy in metabolism; |
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| 11.2 Photosynthesis | 11.2.1 Define photosynthesis; 11.2.2 Describe the significance of photosynthesis; 11.2.3 State the reactants and products of photosynthesis; 11.2.4 Describe chromatography and spectrophotometry; 11.2.5 Explain the role of chlorophyll and other photosynthetic pigments, light, carbon dioxide and water in photosynthesis; 11.2.6 Describe main events of light dependent reactions (energy conversion, formation of ATP and NADPH); 11.2.7 Compare cyclic and non-cyclic phosphorylation in light dependent reactions; 11.2.8 Describe three phases of light independent (dark) reactions; 11.2.9 Compare C3, C4 and CAM plants; |
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| 11.3 Respiration | 11.3.1 Define cellular respiration, oxidative phosphorylation, aerobic respiration and fermentation; 11.3.2 Differentiate between alcoholic and lactic acid fermentation; 11.3.3 State the role of mitochondria in respiration; 11.3.4 Explain the steps involved in the mechanism of cellular respiration:
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12. Nutrition |
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| 12.1 Nutrition in Plants | 12.1.1 Define nutrition; 12.1.2 Differentiate between autotrophic and heterotrophic nutrition in plants; 12.1.3 Describe various conditions caused by the deficiency of:
12.1.4 Differentiate among various modes of heterotrophic nutrition in plants:
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| 12.2 Nutrition in Animals | 12.2.1 Differentiate among various forms of heterotrophic nutrition in animals:
12.2.2 Classify holozoic heterotrophs:
12.2.3 Classify the types of heterotrophic nutrition on the basis of size of food particle:
12.2.4 Differentiate between intercellular and intracellular digestion; |
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| 12.3 Nutrition in Non-Chordates | 12.3.1 Describe nutrition in amoeba, hydra, planaria and cockroach; 12.3.2 Differentiate between complete and incomplete alimentary canal; |
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| 12.4 Digestion in Human Beings | 12.4.1 Relate the function of each organ of digestive system of the human with its structure:
12.4.2 Discuss the process of digestion of carbohydrates, proteins and lipids in human being; |
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13. Gaseous Exchange |
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| 13.1 Gaseous Exchange in Plants | 13.1.1 Define respiration; 13.1.2 Describe conditions necessary for gaseous exchange; 13.1.3 Differentiate between gaseous exchange in plants through stomata and lenticels; 13.1.4 Describe process and importance of photorespiration; |
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| 13.2 Gaseous Exchange in Animals | 13.2.1 Describe properties of respiratory surface; 13.2.2 Describe process of gaseous exchange in hydra, earthworm and cockroach; 13.2.3 Explain the mechanism of gaseous exchange in fish, frogs and birds; 13.2.4 Differentiate between complete and incomplete ventilation; |
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| 13.3 Respiratory System of Human Being | 13.3.1 Relate the function of each organ of respiratory system of human being with its function:
13.3.2 Explain mechanism of breathing in human beings; |
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| 13.4 Respiratory Disorders | 13.4.1 Discuss causes, symptoms and preventive measures of:
13.4.2 Explain the effects of smoking on respiratory system; |
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14. Transport |
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| 14.1 Introduction | 14.1.1 Define transport in living organisms; 14.1.2 Describe the importance of transport of material in living organisms; |
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| 14.2 Transportation in Plants | 14.2.1 Explain uptake of water and minerals by roots and pathways (apoplast, symplast and vacuolar) involved in it; 14.2.2 Define water potential, osmotic potential and pressure potential; 14.2.3 Calculate water potential of living cells; 14.2.4 Differentiate between plasmolysis and deplasmolysis; |
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| 14.3 Ascent of Sap | 14.3.1 Define ascent of sap; 14.3.2 Explain factors affecting ascent of sap:
14.3.3 Explain mechanism of transpiration pull with reference to cohesion tension theory, root pressure and imbibition; |
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| 14.4 Transpiration | 14.4.1 Define transpiration; – Differentiate among types of transpiration (cuticular, lenticular and stomatal transpiration); – Explain mechanisms involved in opening and closing of stomata:
14.4.4 Analyse the effect of various factors affecting the rate of transpiration:
14.4.5 Discuss why transpiration is considered as a necessary evil; |
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| 14.5 Translocation | 14.5.1 Define translocation; 14.5.2 Explain mechanism of phloem translocation (diffusion and pressure flow hypothesis); |
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| 14.6 Transportation in Animals | 14.6.1 Describe the process of transportation in amoeba, hydra and planaria; 14.6.2 Describe circulatory system of vertebrates; 14.6.3 Exemplify open and closed circulatory system; 14.6.4 Differentiate between single circuit and double circuit circulation; 14.6.5 Describe evolutionary variation in vertebrates’ heart (fish, amphibians, reptiles, birds and mammals); 14.6.6 Compare circulatory systems of fishes, amphibians, reptiles, birds and mammals; |
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| 14.7 Circulatory System of Human Beings | 14.7.1 Describe the composition and functions of blood in human beings; 14.7.2 Describe disorders of blood:
14.7.3 Discuss preventive measures and treatment of blood disorders; |
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| 14.8 Cardiovascular Disorders | 14.8.1 Describe atherosclerosis, arteriosclerosis, thrombus formation embolus, coronary thrombosis, myocardial infarction, stroke and hypertension; 14.8.2 Describe causes, effects and preventive measures of atherosclerosis, arteriosclerosis, myocardial infarction and hypertension; 14.8.3 Define haemorrhage; |
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| 14.9 Immune System | 14.9.1 Define immunity; 14.9.2 Explain innate defence (barrier defence and internal defence); 14.9.3 Explain adaptive immune system (humoral response and cell mediated response); 14.9.4 Differentiate between primary and secondary immune responses; 14.9.5 Differentiate between active and passive immunity; |
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